Athletic Club Iker Muniain is the major injury absentee for the hosts, with the young attacking midfielder sidelined for six to seven months after damaging his cruciate ligaments.
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Valencia Jose Gaya joins Enzo Perez on the treatment table for the away side, with Lucas Orban likely to be drafted into the team at left-back as a result.
Athletic Bilbao: Iraizoz; Balenziaga, Etxeita, Gurpegi, Marcos; Rico, Jose; Gomez, Benat, Williams; Aduriz
Valencia: Alves; Barragan, Mustafi, Otamendi, Orban; Paul, Fuego, Gomes; Rodrigo, Negredo, Piatti