On 12 June 2017, Silva moved to Italian Serie A side A.C. Milan on a five-year contract for a fee of €38 million with the additional €2 million depending on objectives.
Silva made his debut for the club on 27 July, playing 24 minutes in the 1–0 win against CS Universitatea Craiova for the third qualifying round of the UEFA Europa League.
Watch video Andre Silva – Incredible Skills, Goals & Assists – 2017/18 (Video HD):